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D., Ph.D., and Shlomo Shinnar, M.D., Ph.D.: Long-Term Mortality in Childhood-Onset Epilepsy Few research have evaluated long-term mortality in well-characterized cohorts of children with epilepsy. With several notable exceptions,1-3 studies involving adults are often retrospective.4-11 In pediatric series, the follow-up is generally 5 to a decade.12-18 In every series, autopsy confirmation of an absence of other notable causes of death, that is necessary to confirm unexpected, unexplained death in persons with epilepsy,19 is uncommon. We present mortality data from a cohort of 245 subjects with childhood-onset epilepsy who have been adopted for 40 years.