Aetna, located in Connecticut, is the fourth main insurer sanctioned in this way in two years. In the last two years, the national government has transformed how it enforces Medicare regulations, stated Robert Zirkelbach, a spokesman for America’s MEDICAL HEALTH INSURANCE Plans, a trade group. Although the government has always provided oversight, Zirkelbach said, there have been more sanctions and more general public announcements of the sanctions . CQ Healthbeat: Aetna, in a statement released by its corporate headquarters in Hartford, Conn., said that it is fully cooperating with the federal government and is working to resolve the issues raised by CMS as quickly as possible.Agios believes in the potential of small molecules to be disease-modifying therapeutics for rare genetic disorders by targeting the precise metabolic defects driving these diseases. We expect that the results from this healthy volunteer research will enable us to go AG-348 rapidly into a research in sufferers with PK insufficiency. Preclinical studies have demonstrated that AG-348 activates a wide spectrum of PK-R mutant proteins, and corrects the metabolic defects found in patient-derived bloodstream samples, said Scott Biller, chief scientific officer of Agios. These data support the hypothesis that medication intervention with AG-348 will restore glycolytic pathway flux and normalize reddish blood cell metabolism.