ASSURE study of experimental agent to improve HDL yields ‘disappointing and surprising’ results The search continues for an agent that increases high-density lipoprotein and reduces arterial plaque, after the experimental apolipoprotein A1 inducer, RVX-208 failed to do so in the ApoA1 Synthesis Stimulation and Intravascular Ultrasound for Coronary Atheroma Regression Evaluation study. The lack of efficacy of RVX-208 is ‘disappointing and astonishing, given promising earlier results,’ noted lead investigator Stephen Nicholls MBBS, PhD, Deputy Director at the South Australian Medical and Health Research Institute, Professor of Cardiology at the University of Consultant and Adelaide Cardiologist at the Royal Adelaide Hospital in Adelaide, Australia.Chronic kidney disease was indicated as a medical medical diagnosis in the statements of 5.2 percent of donors by the fifth anniversary of donation. Older age in donation was connected with an increased threat of postdonation hypertension of 6 percent each year . As compared with white kidney donors, dark donors had a relative increase of 52 percent in the risk of diagnosed hypertension and a rise of 31 percent in the chance of drug-treated hypertension. The risk of diagnosed hypertension was 36 percent higher among Hispanic donors than among white donors, even though risk of drug-treated hypertension didn’t differ between the two groups significantly.