‘Further research in younger individuals is needed, but it stands to reason that early detection and intervention – – such as controlling cardiometabolic elements and tighter glycemic control, that assist prevent microvascular complications – – could reduce or delay these cognitive complications also.’ Type 1 diabetes generally is diagnosed in kids and young adults and occurs when the body does not produce insulin, a hormone that is needed to convert glucose into energy. Dr. Rosano and her co-authors examined mind MRIs, cognitive assessments, physical examinations and medical histories on 97 people who have type 1 diabetes and 81 of their nondiabetic peers.Strategies Trial Oversight and Style We conducted this randomized, double-blind, parallel-group, placebo-controlled, event-driven study at 1139 centers in 51 countries. The analysis was designed to determine the effect of the addition of ivabradine to standard therapy in patients with stable coronary artery disease.12 The study protocol, available with the full text of this article at NEJM.org, was approved by the ethics committee in each participating institution. The trial was sponsored by Servier. The executive committee, which included non-voting representatives of the sponsor, was responsible for the study design, the interpretation of the results, the writing of the manuscript, and the decision to send the manuscript for publication.