Labor was induced because of fetal postmaturity and oligohydramnios. Immediately after birth, severe tachypnea and respiratory distress requiring high-circulation supplemental oxygen created in the infant. On the first day of life, upper body radiography showed serious reticulonodular changes . On day 13, laboratory investigations revealed renal failure and the nephrotic syndrome , and peritoneal dialysis was initiated on day time 14. Abdominal ultrasonography demonstrated small, hyperechoic kidneys . Respiratory distress persisted, and recurrent vomiting episodes with secondary aspiration associated with life-threatening occasions and respiratory tract infections complicated the training course.The exogenous addition of PTX3 to PTX3-deficient neutrophils reversed the practical deficit, confirming that the innate antifungal mechanisms of these cells are compromised by too little sufficient PTX3 to successfully counter the fungus. Our observation that both 48A and 48D types of PTX3 bound conidia effectively further supports a scarcity of PTX3 in quantity, not in quality. It is also possible that PTX3 insufficiency adversely impacts antifungal mechanisms mediated by various other innate immune receptors27 or leukocyte recruitment in the lungs.28 Whatever the mechanism , the absence of a link between genetic variants in transplant recipients and invasive aspergillosis shows that epithelial PTX3 has a smaller part, if any, in the immune response to the fungus.