Knowledge of the genetic determinants of valvular calcification may help elucidate the mechanisms underlying valvular cardiovascular disease and could foster the development of new therapies. We performed a genomewide association study of aortic-valve calcification and mitral annular calcification in three population-structured cohorts. The results were confirmed in additional multiethnic cohorts through computed tomographic evaluation of valvular calcification or identification of clinically obvious valvular heart disease. Methods Study Populace and Design This investigation was initiated within the Cohorts for Heart and Aging Research in Genome Epidemiology consortium. The CHARGE consortium can be an ongoing investigator-powered collaboration among many large, population-based cohort studies where genomewide genotype data have been obtained and comprehensive individual phenotyping for a number of clinical characteristics has been performed.Another area of concern is smoking cigarettes. The take action of smoking cigarettes regularly places you at a high degree of risk for developing the deadly disease of conversation. You know more about coronary heart disease Now, you can better understand the dire circumstance that it represents. Also, you are more informed in what you can do to be able to lessen your chances of developing this deadly disease. If you believe you are at risk, you should get hold of your doctor to be able to work out an idea that may keep your heart healthy and safe.