‘We end 2010 on a higher be aware and well positioned to engage the 112th Congress,’ concluded Fenton Ambrose.. LCA CEO and President Laurie Fenton Ambrose said, ‘This is actually the most significant year to day and looking back years from right now 2010 will be seen as the turning stage.’ ‘We are creating a solid coalition of support within Congress and within the very best public health, medical and social justice institutions in the country,’ she said.Based on our estimates of risk, women with loss-of-function mutations in PALB2 should be studied to determine whether enhanced surveillance for breast cancer, consistent with that offered to women with mutations in BRCA2, can influence outcomes. Risk-reducing surgical options could be tested. We found a nonsignificant increase, by one factor of 2.3, in the chance of ovarian malignancy for PALB2 carriers. The question of whether loss-of-function mutations in PALB2 confer a predisposition to ovarian cancer will demand larger studies to handle. We also estimated that the chance of breast cancers for male PALB2 mutation carriers is certainly increased by one factor of 8, which is consistent with previous reports,7,35,36 however the confidence interval because of this estimate was very large.