Because errors in recombination can possess catastrophic consequences.

Having less 53BP1 avoided the proper reshuffling of genetic material during recombination. Whenever a section of genetic materials is cut loose to become recombined, it must be quickly reattached if not it dangers migrating to another chromosome in a process called translocation, a common cause of cancer. In regular VJ recombination, that will not happen, but sometimes the genetic material that is being reshuffled has to travel to a comparatively distant place on its chromosome. The researchers found that that procedure for long-distance DNA end-joining, happened 2.5 times much less often in mice that lacked 53BP1. Related StoriesStudy reports discovery of new class of DNA fix enzymeUAB researcher awarded NIH grant to study pathogenesis of thrombotic microangiopathyResearchers reveal how charged gold nanoparticles influence framework of DNA and RNAAnd, when recombination falters, significant consequences follow. Continue reading Because errors in recombination can possess catastrophic consequences.

Lisa Rosenbaum.

So EHRs will be only as good as the product quality metrics they’re designed to capture; technology can’t get over fundamental measurement issues. We measure a lot of things that have no worth to patients, while much of what individuals do worth, including our interest, remains unmeasurable. Why, Wachter asks, do we do nothing comparable in health care? In a moving passage, Wachter speaks with a renowned surgeon who once spent his evenings before surgery reading his notes on another day’s patients. No longer. His notes have already been rendered homogeneous by the tyranny of clicks and auto-populated fields uselessly. I can’t actually picture their faces. The blanks on our screens could be filled with words, but the process of understanding cannot be auto-populated. Continue reading Lisa Rosenbaum.

4 percent of the Maryland law prescription medication.

4 percent of the Maryland law, Wal-Mart health benefits health benefits violated ERISA Could California proposal toA federal appeals court ruling against a Maryland law that required large employers could Occupational Safety and expand benefits California Governor Arnold Schwarzenegger universal health care proposal, the Los Angeles Times reports is based. The stepped Maryland law, January 2006, would have required employers in Maryland spend with 10,000 or more employees by at least 8 percent of personnel costs in the health care or contribute to a state fund for the uninsured. Wal-Mart was the only employer in Maryland, businesses affected prescription medication . – ‘Courtesy of you, the entire Kaiser Daily Health Policy view Report, search the archives, or sign up for email delivery at Kaiser Daily Health Policy Report strongly supports imperial network a free service of The Henry J. Published. Kaiser Family Foundation. 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

Plans and otherPPOs, HMOs To Consumer-Directed Health Plans, Study FindsU.S. Workers prefer PPO or HMO insurance plans, rather than consumer-directed health plans to enroll, according to a Center for Study Health System Change study released Friday the AP / Los Angeles Times reported. The study, using data, using data from an earlier survey of 2,122 randomly voted private and nonfederal company that 39 percent the 2.7 million U.S. Citizens enrolled employer-sponsored consumer-directed health plans no no other health insurance options. Among workers offered a choice of health insurance plans, including consumer – directed plans, and other options, such as HMOs or PPOs selected 19 percent of the consumer directed plan. Comparable selection rates for PPO and HMO plans when employees were given the option of choosing from a variety of plan types, 55 percent and 40 percent were be. Jon Fork, author of the study and vice president of the HSC, Los Angeles Times, plans have lower premiums could encourage employees to PPOs or HMOs, much much lower deductibles. According to the study, a single employee was the monthly premium for a PPO $ 61, not statistically different from the $ 56 fee for the consumer-driven plan, while consumer directed plans had an average deductible of 1 compared to a $ 261 deductible for PPOs. Fork adds that consumers may choose not consumer-driven plans, because it are being careful financially for their health care decisions. Fork said, Most Americans are risk averse Do not financial decisions. . Karen Ignagni, president and CEO of America ‘s Health Insurance Plans, said AHIP surveys show that the registration of the consumer directed plans growing , and that 30 percent of small businesses surveyed do not offer any health insurance options to consumer directed plans became available (Agovino, AP / Los Angeles Times, u003c/ bru003e The HSC study is available online. Courtesy of you, the entire Kaiser Daily Health Policy view Report, search the archives, or sign up for email delivery at Kaiser Daily Health Policy Report strongly supported kaiser network a free service of The Henry J. Published. Kaiser Family Foundation. 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved. Continue reading 4 percent of the Maryland law prescription medication.

There are still those whose mantra bronzed is beautiful remains unshaken.

Our study set out to find whether particular individuals, those who classify themselves as frequent tanners particularly, exhibit addictive behaviors toward tanning. Dr. Hornung and her collaborator, Solmaz Poorsattar, asked a complete of 385 male and female university students at the University of Washington in Seattle to comprehensive a multiple-choice questionnaire that included questions about their personal tanning methods and those of their family and friends. In addition, four questions in the study comprised a modified version of the decrease also, annoyed, guilty, eye-opener questionnaire tool. CAGE, which is a proven testing tool frequently used to recognize SRD in regards to to alcohol, was utilized to determine whether participants demonstrated symptoms of an SRD to UV light. Only students who reported ever purposely tanning were asked to total this portion of the questionnaire. Continue reading There are still those whose mantra bronzed is beautiful remains unshaken.

Consider them to your neighborhood pharmacist who will be able to dispose of them safely.

Instead, consider them to your neighborhood pharmacist who will be able to dispose of them safely. Recent research** by NPS discovered that only 20 percent of individuals who keep a Medicines List remember to record their over-the-counter and complementary medications along with their prescription medicines. Furthermore, not even half carry their list with them at fine times. Exclude medications from your cabinet previous their expiry day or that are no more needed. If in doubt, ask your physician or pharmacist. If a medicine has an expiry month, this implies the end of that month. Continue reading Consider them to your neighborhood pharmacist who will be able to dispose of them safely.

Confounding the results.

‘Urine drug screening can be important in any population studies looking at the prevalence of narcolepsy in adolescents, especially with the recent pattern in marijuana decriminalization and legalization.’ Related StoriesLoyola Medication, Palos Community Medical center jointly release innovative telemedicine programGlan Clwyd Hospital N Wales invest in Esaote's G-Scan MRI device for weight-bearing scanningHeart of the Rockies Regional INFIRMARY selects Aprima EHRTypically, a diagnosis of narcolepsy is manufactured after a clinical evaluation for excessive daytime sleepiness, followed by a standardized multiple rest latency test comprising 4-5 scheduled day time nap opportunities in which speed of sleep onset and presence of quick eye movement sleep are both calculated.

Shows the right time span of symptomatic recurrent venous thromboembolism and death linked to venous thromboembolism. Results of the evaluation of the combined result of all thromboembolic events are shown in Table 2. Bleeding Major bleeding occurred in four individuals who had been receiving placebo, as compared with two patients who were receiving 2.5 mg of apixaban and one individual who was simply receiving 5 mg of apixaban . The difference in the price of major bleeding with the 2 2.5-mg dose in comparison with the 5-mg dose was 0.3 to 0.5). Clinically relevant nonmajor bleeding occurred in 19 sufferers who were receiving placebo, as compared with 25 patients who were receiving 2.2 to 0.9) and 34 patients . Continue reading Confounding the results.

Acidity Causes.

Finding the right herbal item from list might not be a simple task at all. In this content, we are going to see among the best treatments for treating acidity problems. Including licorice root tea in diet plan is found to become as a secure cure for most stomach complaints. Today, you can find licorice root tea powder from online markets easily. From preventing acid reflux disorder Apart, this particular herbal extract act as a protective level for esophagus. This function is found to be very helpful to save the mucilage coating of esophagus. Should you have queries concerning its consumption, feel free to seek guidance from health professionals. Indian gooseberry is another safe get rid of for acid reflux issues. Today, Indian gooseberry is definitely one of the best herbal remedies recommended by health professionals.

They are available in oral forms and as nasal sprays. They must be used for just a few days, as they may have unwanted effects such as high blood pressure, fast heartbeat, and nervousness.

Alcohol intake increases risk of many cancers A large group of distinguished researchers published a very detailed and rather complex paper describing the association between alcohol usage and cancer in the BMJ. It really is based on data from the EPIC research in European countries, with a mean follow-up of 8.8 years for a lot more than 300,000 subjects. Continue reading Acidity Causes.

New educated class is more health mindful than its predecessors.

But if you wish to get health instead of money then you should choose beauty care and attention items made with natural elements. Organic beauty products can be found at selected places. It is totally incorrect as these goods can be purchased by leading departmental shops and in addition by online stores. Demand for organic soaps and lotions is growing and every wellness products store is selling organic beauty products to take advantage of the demand.. Advantageous organic beauty products People are using organic beauty products because they are alert to the disadvantages of using chemical rich ordinary soaps and lotions. New educated class is more health mindful than its predecessors. Today people find out the after effects and unwanted effects of using soaps with high concentration of chemical substances and petroleum byproducts.

However these options usually do not address the resulting vertebrae breakdown, height loss and other resulting complications. Balloon kyphoplasty can be a minimally invasive process of severe vertebral fractures that reduces and corrects the vertebral deformity by inserting expandable balloon tamps and filling it with bone cement. In 2007, 46,000 inpatient kyphoplasty methods were performed in the usa, based on the Nationwide Inpatient Sample, Health care Utilization and Cost Project coordinated by the Company for Healthcare Analysis & Quality. Results were offered today from a study of 149 patients treated with balloon kyphoplasty and 151 sufferers treated with non-surgical treatment. Continue reading New educated class is more health mindful than its predecessors.

Adjuvant cisplatin for NSCLC raises non-cancer mortality risk By Afsaneh Gray.

Certified from medwireNews with permission from Springer Healthcare Ltd. All privileges reserved. Neither of these ongoing parties endorse or recommend any commercial products, services, or equipment.. Adjuvant cisplatin for NSCLC raises non-cancer mortality risk By Afsaneh Gray, medwireNews Reporter Re-evaluation of data from the International Adjuvant Lung Cancer Trial indicates that cisplatin-based adjuvant chemotherapy increases the long-term risk of non-malignancy mortality in individuals with non-small-cell lung malignancy . Nevertheless, the chemotherapy also decreased the chance of local cancers relapse and of non-brain metastases, with the researchers estimating that more than half of patients might benefit from the treatment, whereas the harmful results on non-cancer mortality just became significant after 5 years.5 years.

14 issue of the U.S. Centers for Disease Control and Prevention’s Morbidity and Mortality Weekly Record.

4 Things You Must Do When You Notice HAIR LOSS In mid life, a large number of women have problems with an unexplained thinning of hair. It might show as receding locks line or bald spots on the scalp. This is often as devastating as an all natural calamity. It is like a calamity taking place right on your head! The situation appears to worsen, as women hardly ever have a solution at hand. They experience helpless. They are pressured to see their beloved locks part from the scalp. Is there anything you can do? Yes. Here are certain items you can and should do. Consult a doctor Get your testosterone amounts checked. Continue reading Adjuvant cisplatin for NSCLC raises non-cancer mortality risk By Afsaneh Gray.

Often referred to as a superfood generic cialis.

10 health advantages of cucumbers Cucumbers are the fourth most cultivated veggie in the world and regarded as among the best foods for your own body’s overall health, often referred to as a superfood generic cialis . Cucumbers tend to be sprayed with pesticides so it is vital that you buy organic or even better, grow them yourself. Here are 10 Benefits of cucumbers: 1.Quick pick me-up – Cucumbers are a good way to obtain B vitamins. Deposit your espresso and sodas and eat a cucumber slice. 2. Rehydrates body and replenishes daily nutritional vitamins – Cucumbers are 95 % water, keeping the physical body hydrated whilst helping your body eliminate toxins. Cucumbers have the majority of the vitamins the physical body requires in a single day. Do not forget to leave the skin on because the skin contains a good amount of vitamin C, about ten % of the daily-suggested allowance. 3. Pores and skin and hair care – If you don’t like to eat the skin, it can be used for skin sunburns and irritations since aloe would be used. Place a slice over puffy eye and its anti-inflammatory properties lessen puffiness. The sulfur and silicon in cucumbers help stimulate hair growth. 4. Fight cancers – Cucumber are recognized to include lariciresinol, pinoresinol, and secoisolariciresinol. These three lignans possess a solid history of research regarding the reduced risk of several malignancy types, including breast cancer, ovarian cancer, uterine cancer and prostate cancer. 5. Home care – Eliminates a foggy mirror. Before going for a shower, rub a cucumber slice along a mirror and it will get rid of the mirror fogging up. Instead of WD40, have a cucumber slice and rub it along a squeaky hinge and your door will minimize squeaking. 6. Relieves poor breath – Have a slice of cucumber and press it to the roofing of your mouth together with your tongue for 30 seconds, the phytochemcials will eliminate the bacteria in your mouth responsible for causing bad breath. 7. Hangover cure – In order to avoid a morning hours hangover or headache; eat a couple of cucumber slices prior to going to bed. Cucumbers contain enough sugars, B nutritional vitamins and electrolytes to replenish many essential nutrients, reducing the strength of both hangover and headaches. 8. Aids in weight digestion and reduction – Because of its low calorie and high water content, cucumber can be an ideal diet for those who are searching for weight loss. The high water content material and dietary fiber in cucumbers are amazing in ridding your body of toxins from the digestive tract, aiding digestion. Daily consumption of cucumbers could be regarded as a remedy for chronic constipation. 9. Treatments diabetes, reduces cholesterol and controls blood circulation pressure – Cucumber juice consists of a hormone which is necessary by the cellular material of the pancreas for making insulin which includes been found to end up being good for diabetic patients. Researchers discovered that a compound known as sterols in cucumbers may help reduce cholesterol levels. Cucumbers contain a lot of potassium, fiber and magnesium. These work for regulating blood pressure effectively. This makes cucumbers best for dealing with both low blood pressure and high blood circulation pressure. 10. Promotes joint health, relieves gout and arthritis pain -Cucumber is an excellent source of silica, which may help promotes joint health by strengthening the connective tissues. They are rich in vitamin A also, B1, B6, C & D, Folate, Calcium, Magnesium, and Potassium. When mixed with carrot juice, they are able to alleviate arthritis and gout pain by lowering the uric acid levels.

100,000 Iraqi civilians have passed away as a total consequence of the March 2003 invasion Public-health professionals from the USA and Iraq estimate that around 100,000 Iraqi civilians have died due to the March 2003 invasion-the majority getting violent deaths among women and children associated with military activity. Results of the research, carried out among clusters of Iraqi households last month, can be published on-line by THE LANCET. Les Roberts and colleagues did a study to investigate the result of the Iraq battle on civilian deaths by comparing mortality through the 14.6 months prior to the March 2003 invasion with the 17.8 months after it. The investigators interviewed a complete of 988 households from 33 randomly selected neighbourhoods of Iraq; since January 2002 in those households reporting deaths, the date, cause, and situations of violent deaths were recorded. Overall, the risk of death was 2.5 times greater after the invasion, although the risk was 1.5 times higher if mortality around Falluja is excluded. The investigators estimate that a 1.5 times increase in deaths equates to an excess of 98,000 deaths relating to the Iraq conflict, although this estimate will be much better if Falluja data is roofed. Violence was the root cause of death following the invasion; Violent deaths were widespread, reported in 15 of 33 clusters surveyed, and were mainly related to coalition forces . Most individuals killed by coalition forces were women and children reportedly. The risk of loss of life from violence in the period after the invasion was 58 times greater than in the period before the war. The significant reasons of death before the invasion were coronary attack, stroke, and chronic illness. Dr Roberts remarks: ‘Producing conservative assumptions, we believe about 100 000 extra deaths or even more have happened since the 2003 invasion of Iraq. Violence accounted for most of the excess deaths and air strikes from coalition forces accounted for most violent deaths. We have shown that the assortment of public-health information can be done even during periods of intense violence. Our results require further verification and really should lead to changes to reduce noncombatant deaths from air strikes.’ Lancet Editor Richard Horton adds within an accompanying commentary: ‘The study we publish today was completed under the many testing of circumstances – a continuing war. And therefore certain limitations were unavoidable and have to be acknowledged right away. The true number of population clusters chosen for sampling is small; the self-confidence intervals around the point estimates of mortality are wide; the Falluja cluster has an specifically high mortality therefore is atypical of all of those other sample; and there is the prospect of recall bias among those interviewed clearly. This remarkable good article represents the initiatives of a courageous group of scientists. To have included more clusters could have improved the accuracy of their findings, but at a massive and unacceptable risk to the team of interviewers who gathered the primary data. Despite these unusual difficulties, the central observation – specifically, that civilian mortality since the pugilative war offers risen because of the ramifications of aerial weaponry – is convincing. This result requires an urgent political and army response if the confidence of normal Iraqis in the mostly American-British occupation is usually to be restored.’ Related StoriesE-cigarette use among American high school students reaches an all period highElectronic cigarettes and cigarette smoking cessation: an interview with Professor Peter HajekReducing premature deaths from noncommunicable diseases: an interview with Dr Shanthi Mendis, WHOHe proceeds: ‘Roberts and his co-workers submitted their function to us at the beginning of October. Their paper has been peer-reviewed extensively, revised, edited, and fast-tracked to publication due to its importance to the evolving security circumstance in Iraq. But these results also raise questions for those far removed from Iraq – in the governments of the countries responsible for launching a pre-emptive battle. In preparing this pugilative war, the coalition forces – specifically those of the united states and UK – will need to have considered the probably effects of their activities for civilians. And these effects presumably influenced deployments of military, provision of supplies, and investments in creating a secure and safe physical and individual infrastructure in the post-war setting. With the admitted advantage of hindsight and from a public-health perspective purely, it is crystal clear that whatever planning did take place was grievously in mistake. The invasion of Iraq, the displacement of a cruel dictator, and the attempt to impose a liberal democracy by drive have, by themselves, been insufficient to bring peace and protection to the civilian human population. Democratic imperialism has led to more deaths not fewer. This political and military failure continues to cause scores of casualties among non-combatants. It is failing that deserves to be a serious subject for study. But this survey is more than a piece of academic investigation.’ Dr Horton concludes: ‘An essential principle of public wellness is harm decrease. But harm cannot be diminished by person members of society alone. The lives of Iraqis are currently being formed by the guidelines of the occupying forces and the militant insurgents. For the occupiers, successful the peace now needs an intensive reappraisal of strategy and tactics to prevent further unnecessary individual casualties. For the sake of a country in crisis and for a people under daily threat of violence, today must modify heads and also pierce hearts the data that we publish.’. Continue reading Often referred to as a superfood generic cialis.

Van Berge Henegouwen.

All patients provided written informed consent. The institutional review panel at each participating center approved the study protocol.8 The protocol, including the statistical analysis plan, is available with the entire text of this content at NEJM.org. No commercial support was involved in the scholarly study; the drugs were purchased. No-one who is not an writer contributed to the manuscript. The first, 4th, and last authors attest to the accuracy and completeness of the reported data and the fidelity of the analysis to the process.

Since the initial outbreak of bird flu in 2003, the virus offers killed 62 people in Thailand, Vietnam, Indonesia and Cambodia. At that right period China declared it had eradicated the condition. As hens are kept in related conditions in China as in every south-east Asian countries, there’s been widespread concern about the validity of the Chinese claims. Six people died in an earlier outbreak in Hong Kong in 1997. While China has not to date recorded an individual human case officially, it has led to repeated rumours on anti-government websites based of authorities cover-ups of deaths abroad. Continue reading Van Berge Henegouwen.

In a collaborative venture with Social Science Study Solutions of Press.

Participating groups may also use a variety of study strategies that best suit their needs: web, phone, paper surveys, or any mixture thereof. Natural response data and response prices collected through internet and mobile phone surveys will be available to participating medical groupings with a web portal in real time, so that they can track the improvement of the surveying work as well as get a sense of the initial results.. AMGA adds brand-new distribution solutions to Patient Satisfaction Benchmarking Survey The American Medical Group Association today announced the addition of two fresh distribution methods to their Patient Fulfillment Benchmarking Survey: Interactive Tone of voice Response phone and web-enabled survey distribution methods. In a collaborative venture with Social Science Study Solutions of Press, Pennsylvania, the association provides these new methods to the traditional paper survey that is distributed by reception personnel and completed by the patient on-site.

Online DNA mapping assists siblings find one another 23andMe is part of a fledgling industry that allows customers to peek into their genetic code for details about their ancestry and future health. The company’s saliva-based products have attracted scrutiny for claiming to help users detect if they are likely to develop illnesses like breast cancer, heart disease and Alzheimer’s. The biology of how DNA variations result in certain diseases is still poorly understood actually, and many geneticists say such checks are built on flimsy evidence. Continue reading In a collaborative venture with Social Science Study Solutions of Press.

The initiative&39.

Furthermore, Accelerated Cure Project's collaborating MS clinics around the country are alerting their patients to the chance to join. ‘Understanding the MS knowledge from the patient's perspective is key to improving the caution of people with MS also to creating effective treatment paradigms,’ commented Timothy Coetzee, Ph.D., Chief Advocacy, Solutions, and Study Officer, National Multiple Sclerosis Culture. By providing important wellness data, people with MS have a direct impact in advancing study and improving quality of life.’ Data gathered at iConquerMS.org may enable insights on a wide variety of topics, such as symptoms, treatments, and quality of life, and could lead to improved diagnoses, better treatment outcomes, and, ultimately, remedies for MS.

These hormones help the physical body cope with physical and emotional stress by increasing the heartrate and blood pressure.. Admitted: Conventional cancer remedies sterilize women Most American women who find out they have cancers are confronted by their doctors with 3 choices for treatment, which include surgery, radiation and chemotherapy, all of which greatly increase the chance they’ll never be able to procreate again. Yet, rarely will any doctor offer those females the fourth choice of treatment, which will not endanger their fertility whatsoever, and does not require taking medication even. Continue reading The initiative&39.

But that doesnt imply that it still isnt an issue.

‘What that’s informing us is nearly all teen mothers want to avoid pregnancy and are taking steps in order to avoid a do it again pregnancy. However the challenge is one in five are using the most effective method of doing that.’ Sex rates ‘miniscule’ for young adolescents New York City’s fresh teen pregnancy PSAs make use of crying infants to send message Teen birth rates hit historic low in U.S. Repeat teen births were highest among American Indian/Alaska natives , Hispanics and non-Hispanic blacks . Non-Hispanic whites had the lowest price at 14.8 %. Texas had the most do it again teen births at 22 %, while New Hampshire rates were at 10 %.

What’s more, the situation is only going to get worse, thanks in large part to the present chaotic circumstance along the U.S. Southwest border. It really is lawless and uncontrollable, taxing already scarce resources. For instance, reports have said recently that as much as 70 % of Border Patrol officers have pulled off of actually patrolling the border because they’re processing tens of thousands of illegal immigrants, most of the children [ But more than that, many of these young children will tend to be permitted to stay in the U.S., thanks to President Obama’s 2015 policy change that deemphasizes deportation [ That means taxpayers will have to shoulder the burden to deal with them in addition to older illegal immigrants, many of whom don’t have any skills, are illiterate and also have health problems. Continue reading But that doesnt imply that it still isnt an issue.

Patient safety is a fundamental principle of health professional practice and health care systems http://tadalafilprix.com/cialis-avis.

All the members of the healthcare team have a responsibility for the quality and safety of care they offer. Patient safety is a fundamental principle of health professional practice and health care systems. http://tadalafilprix.com/cialis-avis

This was an important finding of the latest Mount Isa Medical Delegation Conference, a meeting of experts from Australia and overseas organizations including the University of Queensland and James Cook University. Continue reading Patient safety is a fundamental principle of health professional practice and health care systems http://tadalafilprix.com/cialis-avis.

At its annual National Teaching Institute & Critical Care Exposition with the theme Dare To.

AACN's NTI runs Saturday, May 18, through Thursday, May 23, at the Boston Convention & Exhibition Center, with the Westin Boston Waterfront Hotel hosting official events also. AACN expects attendance to best 7,000 nurses you need to include many at the forefront of analysis, academia, staff development and management. NTI, the world's largest conference for nurses who care for large acuity and critically ill patients, contains the Critical Care Exposition, the biggest and most comprehensive tradeshow designed for acute and critical caution nurses. Spread over 200,000 square feet will be a lot more than 400 exhibits that encompass cutting-edge healthcare equipment, devices, pharmaceuticals and supplies.

Listed below are 5 ways as to how abortion affects people: The perception One has to understand that the essential meaning of abortion goes with the perception. For a few, it might mean killing the child before birth forcefully. Although scientifically it really is tested that you cannot eliminate a baby unless it is fully formed, which isn’t till the first-trimester ends, people still believe that abortion means killing a kid. The analogy for people who think likewise might be this. Just like how we are facing disasters by forcing the earth to fulfill our needs, in a similar fashion when the infant is forced out to death, the reproductory organs of a woman are affected adversely. Continue reading At its annual National Teaching Institute & Critical Care Exposition with the theme Dare To.