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Michael J. Davies, M over the counter .P.H., Ph.D., Vivienne M. Moore, M.P.H., Ph.D., Kristyn J. Willson, B.Sc., Phillipa Van Essen, M.P.H., Kevin Priest, B.Sc., Heather Scott, B.Mgmt., Eric A. Haan, M.B., B.S., and Annabelle Chan, M.B., B.S, D.P.H.: Reproductive Technology and the chance of Birth Defects Consistent evidence from individual studies, including registry-based cohort research1,2 and meta-analyses, has linked assisted conception involving in vitro fertilization or intracytoplasmic sperm injection with an increased risk of birth defects.3-8 The associations between the use of these methods and birth defects have appeared to be stronger for singleton births than for multiple births.9,10 It is unclear whether the more than birth defects after IVF or ICSI could be attributable to patient characteristics related to infertility,8 rather than to the treatment, and if the risk is similar across assisted reproductive technology and related therapies.3,10,13 We performed a population-wide cohort study, examining births and pregnancies terminated due to birth defects, to assess the dangers of defects from pregnancy to a child’s fifth birthday across a variety of options for treating infertility as compared with the risk associated with pregnancy that had not been assisted by reproductive technology .

These changes were made so the study design will be consistent with that of modern trials of extended treatment for venous thromboembolism . The analysis was performed relative to the protocol and with the provisions of the Declaration of Helsinki and local regulations. Written informed consent was acquired from all sufferers before randomization. The steering committee had final responsibility for analyses and verification of the info. The writing committee wrote the vouches and manuscript for the accuracy and completeness of the reported data.