John C. Longhurst, director of the Samueli Center and study leader. Acupuncture is a 3,000-year-old form of Chinese medicine that involves inserting needles at specific points on the body to help remedy disease or relieve pain. In previous studies, Longhurst and his UCI colleagues have determined at the cellular and molecular level how acupuncture excites human brain cells release a neurotransmitters that either inhibit or heighten cardiovascular activity. They have found that when an acupuncture needle can be inserted at particular sites on the wrist, inside of the leg or forearm, this triggers the discharge of opioid chemical substances in the brain that reduce excitatory responses in the heart.Histologic Examination The shave-biopsy specimen from Individual 2 showed extensive epidermal hyperplasia with compact parakeratosis and elongated rete pegs . The dermis contained dilated vascular spaces lined with swollen endothelial cells and scattered lymphohistiocytic inflammatory-cell infiltrates in the intervening stroma. No conspicuous regions of necrosis, ulceration, or neutrophilic irritation were identified. Huge, eosinophilic inclusions were seen in the cytoplasm of some keratinocytes that stained intensely with both antiparapoxvirus antibodies . Immunohistochemical staining also revealed a contiguous band of intracellular viral antigens along the superficial aspect of the stratum spinosum .). Discussion The infections defined in both case reports are molecularly confirmed individual parapoxvirus infections linked to deer exposure in the usa.