Richard Edwards.

It’s possible that more sufferers in the control group than in the vertebroplasty group acquired unsatisfactory pain outcomes but that people were unable to identify this difference with our measure of pain intensity. Nevertheless, we utilized a common, validated measure that has been shown to indicate responsiveness to medical improvement. It is possible that vertebroplasty was more effective than the control intervention for a subgroup of sufferers; further research is required to explore this possibility. Finally, it is possible that despite attempts to conceal study-group assignments, some patients became alert to their designated intervention, and the ones who still had discomfort and learned that they were in the control group may have got elected to cross over to the vertebroplasty group.

Impulse oscillometry was utilized to assess respiratory-system level of resistance.10 Inhomogeneity of ventilation distribution was assessed through a multiple-breath technique assessing the lung-clearance index .11,12 Lung volumes were assessed by means of measurements of useful residual capacity by using a helium-dilution technique and forced essential capacity by way of spirometry. The following assessments of lung volumes were also undertaken: functional residual capacity as assessed by means of plethysmography and plethysmographic assessments of total lung capacity and residual volume.Impulse oscillometry was utilized to assess respiratory-system level of resistance.10 Inhomogeneity of ventilation distribution was assessed through a multiple-breath technique assessing the lung-clearance index .11,12 Lung volumes were assessed by means of measurements of useful residual capacity by using a helium-dilution technique and forced essential capacity by way of spirometry. The following assessments of lung volumes were also undertaken: functional residual capacity as assessed by means of plethysmography and plethysmographic assessments of total lung capacity and residual volume.