The trial was sponsored by Pfizer and was conducted in 94 centers world-wide from February 2009 through June 2010. Patients were randomly assigned, in a 4:4:1:1 ratio, to 1 of four regimens: tofacitinib at a dosage of 5 mg twice daily for six months; tofacitinib at a dose of 10 mg daily for 6 months twice; placebo for three months accompanied by 5 mg of tofacitinib twice daily for 3 months; or placebo for 3 months accompanied by 10 mg of tofacitinib twice daily for 3 months. Comparisons with placebo for the initial 3 months had been performed with combined data from both placebo groupings.The CDC record released Thursday is founded on birth certificates for 2007 through 2011. This past year, the CDC announced the overall improvement in teen births: an archive low of 31 births per 1,000 teenagers ages 15 to 19. That comes even close to 42 births per 1,000 five years earlier. The new report targets state figures in 2011: – – Lowest rates are in New Hampshire, Massachusetts, Vermont and Connecticut, each with rates under 17 per 1,000. – – Highest rates overall continue to be in the South, led by Mississippi and Arkansas, each with rates of about 50 per 1,000.