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Preclinical and medical data claim that unacylated ghrelin and its analogs have the potential to address unmet medical requirements in the treatment of type 2 diabetes, Prader Willi syndrome and some ischemia-related conditions, with a novel mechanism of action. Because the clinical program started in 2013, two Phase I trials have been completed in healthy volunteers and overweight/obese subjects. The results indicate that AZP-531 was well tolerated, with improved glucose control and reduced weight in obese topics over a two-week treatment period. The program is in Phase II clinical development for the treatment of Prader-Willi syndrome and in Stage Ib for type 2 diabetes..