Gene-Level Associations with Replication and Triglycerides We following assessed whether rare mutations tested collectively within each gene had been connected with plasma triglyceride levels. An aggregate of rare alleles at APOC3 was associated with lower plasma triglyceride levels .05) . These rare mutations explained 0 collectively.9 percent of the variance in triglyceride levels. The association between plasma lipid levels and APOC3 was due to four different sites within the gene primarily. The missense A43T mutation provides been shown to diminish APOC3 function in vitro.25,26 When the participants of European ancestry had been combined with the participants of African ancestry, approximately 1 in 150 people carried any one of these four loss-of-function mutations .27 To reproduce the results produced from exome sequencing, we genotyped a number of of these four mutations in 34,432 individuals of European ancestry and 7239 participants of African ancestry, independently of the discovery sequencing research., and Desk S9 in the Supplementary Appendix).Anyone will get it, like me, not the poor just. That is the message we have to obtain out there .This article is republished with kind permission from our friends at The Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Statement, search the archives, or join email delivery of in-depth coverage of health policy developments, debates and discussions. The Kaiser Daily Wellness Policy Report is released for Kaisernetwork.org, a free provider of The Henry J. Kaiser Family Foundation. Copyright 2009 Advisory Board Firm and Kaiser Family Basis. All rights reserved.. Allergic contact dermatitis to paraphenylenediamine Here are two cases of allergic contact dermatitis to a chemical substance found in many permanent hair dyes, in temporary henna tattoos and in some inks.